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1994-10-25
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Document 2623
DOCN M94A2623
TI Early diagnostic markers of HIV infection in infants born to HIV
seropositive mothers.
DT 9412
AU Wasi C; Foongladda S; Sutthent R; Likanonsakul S; Louisirirotchanakul S;
Chearskul S; Thongcharoen P; Department of Microbiology, Faculty of
Medicine Siriraj Hospital,; Mahidol University, Bangkok, Thailand.
SO Int Conf AIDS. 1994 Aug 7-12;10(1):262 (abstract no. PB0476). Unique
Identifier : AIDSLINE ICA10/94369952
AB OBJECTIVE: To establish the diagnostic tests for diagnosis of HIV
infection in infants born to HIV seropositive mothers. METHODS: The 108
infants born to HIV seropositive mothers were followed up in the Special
Pediatric Clinic, Siriraj Hospital during April 1992 to December 1993. A
total of 275 subsequent blood samples were investigated for anti-HIV-1
by the two ELISA (Genelavia & Wellcozyme), PA (Fujirebio); p24 antigen
by ELISA after acid treatment for immune complex dissociation (Coulter)
and nested PCR for gag region (SK 380/SK390, SK38/SK39). RESULTS: The 65
infants showed seroreversion at the age of 6 to 15 months and assumed to
be non-infected cases. The 30 infants shown symptoms compatible to
Pediatric AIDS. The 13 infants were asymptomatic but positive for PCR,
and/or p24 Ag and anti-HIV. PCR were positive in 95% (43/45 samples) of
AIDS case and 93% (29/31) in asymptomatic, while p24 Ag was positive in
70% of AIDS case and 58% of asymptomatic ones. DISCUSSION AND
CONCLUSION: PCR is the most sensitive test for early diagnosis of HIV
infection in infants. The positive PCR was nearly 100% at the age of
newborn to 6 months. The p24 Ag after acid treatment is a practical test
but gave only 58% positive in asymptomatic cases.
DE *AIDS Serodiagnosis Enzyme-Linked Immunosorbent Assay Female
Follow-Up Studies Human HIV Antibodies/BLOOD HIV Core Protein
p24/BLOOD HIV Infections/DIAGNOSIS/IMMUNOLOGY/*TRANSMISSION HIV
Seropositivity/DIAGNOSIS/IMMUNOLOGY/*TRANSMISSION HIV-1/*IMMUNOLOGY
Infant Infant, Newborn Male Polymerase Chain Reaction Pregnancy
Pregnancy Complications, Infectious/*DIAGNOSIS/IMMUNOLOGY MEETING
ABSTRACT
SOURCE: National Library of Medicine. NOTICE: This material may be
protected by Copyright Law (Title 17, U.S.Code).